Assay Detail
Binding
CHEMBL901897
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Displacement of [3H]substance P from NK1 human receptor expressed in IM9 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IM-9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Stereoselective synthesis of a novel 2-aza-7-oxabicyclo[3.3.0]octane as neurokinin-1 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.11 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240706 | — | — | 1 | 9.66 |
| CHEMBL441225 | CP-99994 | — | 1 | 9.20 |
| CHEMBL55591 | — | — | 1 | 8.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240706 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL441225 | CP-99994 | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL55591 | — | IC50 | = | 3.4 | nM | 8.47 |