Assay Detail
Functional
CHEMBL901922
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Antiproliferative activity against human K562 cells after 48 hrs
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.66 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | 9.00 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 8.00 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.70 |
| CHEMBL240468 | — | — | 1 | 7.30 |
| CHEMBL238102 | — | — | 1 | 7.22 |
| CHEMBL236411 | — | — | 1 | 7.10 |
| CHEMBL392633 | — | — | 1 | 7.05 |
| CHEMBL394754 | — | — | 1 | 6.89 |
| CHEMBL236992 | — | — | 1 | 6.77 |
| CHEMBL429265 | — | — | 1 | 6.60 |
| CHEMBL236584 | — | — | 1 | 6.55 |
| CHEMBL236805 | — | — | 1 | 6.46 |
| CHEMBL437381 | — | — | 1 | 6.40 |
| CHEMBL236993 | — | — | 1 | 6.36 |
| CHEMBL237880 | — | — | 1 | 6.32 |
| CHEMBL391497 | — | — | 1 | 6.28 |
| CHEMBL396891 | — | — | 1 | 6.10 |
| CHEMBL236776 | — | — | 1 | 6.08 |
| CHEMBL236412 | — | — | 1 | 5.85 |
| CHEMBL236601 | — | — | 1 | 5.77 |
| CHEMBL239833 | — | — | 1 | 5.64 |
| CHEMBL391432 | — | — | 1 | 5.00 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL107 | COLCHICINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL240468 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL238102 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL236411 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL392633 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL394754 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL236992 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL429265 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL236584 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL236805 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL437381 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL236993 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL237880 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL391497 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL396891 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL236776 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL236412 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL236601 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL239833 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL391432 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - | |
| CHEMBL9514 | NOCODAZOLE | IC50 | - | — | - |