Assay Detail
Functional
CHEMBL901934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse vincristine-resistant L1210 cells after 48 hrs by XTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.73 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.16 |
| CHEMBL238102 | — | — | 1 | 6.70 |
| CHEMBL392633 | — | — | 1 | 6.34 |
| CHEMBL238071 | VINDESINE | 3.0 | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL238102 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL392633 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL238071 | VINDESINE | IC50 | > | 5000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 5000.0 | nM | - |