Assay Detail

CHEMBL901972

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Functional

Effect on rat portal vein

ChEMBL ↗

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Target

Portal vein (CHEMBL613654) ↗

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Primary target Portal vein

CHEMBL613654

Anchored from Assay target.

Protein identity Portal vein

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Portal vein
Confidence	1 — Organism
Curated By	Autocuration

Target

Portal vein (CHEMBL613654) ↗

Type	TISSUE
Organism	Rattus norvegicus

Publication

Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.

Perez-Medrano A, Brune ME, Buckner SA, Coghlan MJ, Fey TA, Gopalakrishnan M, Gregg RJ, Kort ME, Scott VE, Sullivan JP, Whiteaker KL, Carroll WA.
J Med Chem (2007) 50 : 6265 -6273
PubMed 17973362 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.09	6.09

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL239514	—	—	1	6.09

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL239514	—	EC50	=	812.83	nM	6.09