Assay Detail
Binding
CHEMBL902037
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Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.19 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437758 | — | — | 1 | 7.79 |
| CHEMBL98110 | — | — | 1 | 7.47 |
| CHEMBL394758 | — | — | 1 | 7.02 |
| CHEMBL394759 | — | — | 1 | 6.47 |
| CHEMBL240775 | — | — | 1 | - |
| CHEMBL240772 | — | — | 1 | - |
| CHEMBL240771 | — | — | 1 | - |
| CHEMBL397829 | — | — | 1 | - |
| CHEMBL240776 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437758 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL98110 | — | IC50 | = | 34.2 | nM | 7.47 |
| CHEMBL394758 | — | IC50 | = | 94.6 | nM | 7.02 |
| CHEMBL394759 | — | IC50 | = | 340.4 | nM | 6.47 |
| CHEMBL240775 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL240772 | — | IC50 | > | 600000.0 | nM | - |
| CHEMBL240771 | — | IC50 | > | 600000.0 | nM | - |
| CHEMBL397829 | — | IC50 | = | 253500.0 | nM | - |
| CHEMBL240776 | — | IC50 | - | — | - |