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Assay Detail

CHEMBL902051

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of H+/K+ ATPase in hog gastric mucosa
ChEMBL ↗
58
Total Activities
58
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Tissue Gastric mucosa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Synthesis and evaluation of 7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a]pyridines as potassium-competitive acid blockers.
Palmer AM, Grobbel B, Jecke C, Brehm C, Zimmermann PJ, Buhr W, Feth MP, Simon WA, Kromer W.
J Med Chem (2007) 50 : 6240 -6264
PubMed 17975907 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 56 5.59 6.90
Activity 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL241009 — — 1 6.90
CHEMBL393803 — — 1 6.80
CHEMBL391054 — — 1 6.50
CHEMBL240781 — — 1 6.40
CHEMBL394240 — — 1 6.40
CHEMBL391255 — — 1 6.30
CHEMBL238691 — — 1 6.30
CHEMBL238488 — — 1 6.30
CHEMBL391897 — — 1 6.20
CHEMBL391059 — — 1 6.20
CHEMBL241626 — — 1 6.20
CHEMBL238895 — — 1 6.20
CHEMBL238692 — — 1 6.10
CHEMBL240575 — — 1 6.00
CHEMBL394017 — — 1 6.00
CHEMBL238474 — — 1 6.00
CHEMBL393764 — — 1 5.90
CHEMBL239705 — — 1 5.90
CHEMBL240574 — — 1 5.90
CHEMBL393977 — — 1 5.80
CHEMBL393804 — — 1 5.80
CHEMBL393217 — — 1 5.80
CHEMBL238688 — — 1 5.80
CHEMBL392580 — — 1 5.70
CHEMBL241202 — — 1 5.70
CHEMBL239310 — — 1 5.60
CHEMBL393954 — — 1 5.60
CHEMBL266714 — — 1 5.60
CHEMBL391246 — — 1 5.50
CHEMBL392764 — — 1 5.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL241009 — IC50 = 125.89 nM 6.90
CHEMBL393803 — IC50 = 158.49 nM 6.80
CHEMBL391054 — IC50 = 316.23 nM 6.50
CHEMBL240781 — IC50 = 398.11 nM 6.40
CHEMBL394240 — IC50 = 398.11 nM 6.40
CHEMBL391255 — IC50 = 501.19 nM 6.30
CHEMBL238691 — IC50 = 501.19 nM 6.30
CHEMBL238488 — IC50 = 501.19 nM 6.30
CHEMBL391897 — IC50 = 630.96 nM 6.20
CHEMBL391059 — IC50 = 630.96 nM 6.20
CHEMBL241626 — IC50 = 630.96 nM 6.20
CHEMBL238895 — IC50 = 630.96 nM 6.20
CHEMBL238692 — IC50 = 794.33 nM 6.10
CHEMBL238474 — IC50 = 1000.0 nM 6.00
CHEMBL240575 — IC50 = 1000.0 nM 6.00
CHEMBL394017 — IC50 = 1000.0 nM 6.00
CHEMBL393764 — IC50 = 1258.93 nM 5.90
CHEMBL239705 — IC50 = 1258.93 nM 5.90
CHEMBL240574 — IC50 = 1258.93 nM 5.90
CHEMBL393977 — IC50 = 1584.89 nM 5.80
CHEMBL393804 — IC50 = 1584.89 nM 5.80
CHEMBL393217 — IC50 = 1584.89 nM 5.80
CHEMBL238688 — IC50 = 1584.89 nM 5.80
CHEMBL392580 — IC50 = 1995.26 nM 5.70
CHEMBL241202 — IC50 = 1995.26 nM 5.70
CHEMBL239310 — IC50 = 2511.89 nM 5.60
CHEMBL266714 — IC50 = 2511.89 nM 5.60
CHEMBL393954 — IC50 = 2511.89 nM 5.60
CHEMBL391246 — IC50 = 3162.28 nM 5.50
CHEMBL392764 — IC50 = 3162.28 nM 5.50
CHEMBL238686 — IC50 = 3981.07 nM 5.40
CHEMBL241417 — IC50 = 5011.87 nM 5.30
CHEMBL241203 — IC50 = 5011.87 nM 5.30
CHEMBL239086 — IC50 = 5011.87 nM 5.30
CHEMBL239920 — IC50 = 5011.87 nM 5.30
CHEMBL392581 — IC50 = 6309.57 nM 5.20
CHEMBL444634 — IC50 = 6309.57 nM 5.20
CHEMBL240993 — IC50 = 6309.57 nM 5.20
CHEMBL240576 — IC50 = 7943.28 nM 5.10
CHEMBL399824 — IC50 = 7943.28 nM 5.10
CHEMBL238479 — IC50 = 10000.0 nM 5.00
CHEMBL238478 — IC50 = 10000.0 nM 5.00
CHEMBL391245 — IC50 = 10000.0 nM 5.00
CHEMBL238896 — IC50 = 12589.25 nM 4.90
CHEMBL240365 — IC50 = 31622.78 nM 4.50
CHEMBL428918 — IC50 = 31622.78 nM 4.50
CHEMBL239704 — IC50 = 39810.72 nM 4.40
CHEMBL391453 — IC50 = 39810.72 nM 4.40
CHEMBL238689 — IC50 = 63095.73 nM 4.20
CHEMBL393406 — IC50 = 63095.73 nM 4.20