Assay Detail
Functional
CHEMBL902064
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Antagonist activity at nAChR in rat striatal slices assessed as inhibition of nicotine-evoked [3H]dopamine release
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.60 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239844 | — | — | 1 | 9.70 |
| CHEMBL269243 | — | — | 1 | 8.70 |
| CHEMBL54331 | — | — | 1 | 8.70 |
| CHEMBL397306 | — | — | 1 | 8.40 |
| CHEMBL55006 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239844 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL269243 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL54331 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL397306 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL55006 | — | IC50 | = | 30.0 | nM | 7.52 |