Assay Detail
Binding
CHEMBL902104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.91 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241682 | — | — | 1 | 8.38 |
| CHEMBL241681 | — | — | 1 | 7.52 |
| CHEMBL391692 | — | — | 1 | 6.03 |
| CHEMBL241517 | GW856804X | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241682 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL241681 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL391692 | — | IC50 | = | 933.0 | nM | 6.03 |
| CHEMBL241517 | GW856804X | IC50 | = | 1900.0 | nM | 5.72 |