Assay Detail
Binding
CHEMBL902105
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Inhibition of human EphB4 by scintillation proximity method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.79 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241682 | — | — | 1 | 9.40 |
| CHEMBL241681 | — | — | 1 | 7.85 |
| CHEMBL241517 | GW856804X | — | 1 | 7.68 |
| CHEMBL239182 | — | — | 1 | 7.36 |
| CHEMBL241516 | — | — | 1 | 7.29 |
| CHEMBL391691 | — | — | 1 | 7.23 |
| CHEMBL248304 | — | — | 1 | 6.96 |
| CHEMBL248100 | — | — | 1 | 6.72 |
| CHEMBL245636 | — | — | 1 | 6.64 |
| CHEMBL391692 | — | — | 1 | 6.41 |
| CHEMBL239180 | — | — | 1 | 6.24 |
| CHEMBL396585 | — | — | 1 | 5.87 |
| CHEMBL396913 | — | — | 1 | 5.66 |
| CHEMBL394384 | — | — | 1 | 5.41 |
| CHEMBL396912 | — | — | 1 | 5.15 |
| CHEMBL247696 | — | — | 1 | - |
| CHEMBL248306 | — | — | 1 | - |
| CHEMBL394383 | — | — | 1 | - |
| CHEMBL394638 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241682 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL241681 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL241517 | GW856804X | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL239182 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL241516 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL391691 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL248304 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL248100 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL245636 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL391692 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL239180 | — | IC50 | = | 575.0 | nM | 6.24 |
| CHEMBL396585 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL396913 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL394384 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL396912 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL247696 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL248306 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL394383 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL394638 | — | IC50 | > | 23000.0 | nM | - |