Assay Detail
Binding
CHEMBL902120
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Inhibition of MMP12
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.21 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240465 | — | — | 1 | 7.30 |
| CHEMBL391288 | — | — | 1 | 6.89 |
| CHEMBL240464 | — | — | 1 | 6.68 |
| CHEMBL440048 | — | — | 1 | 6.41 |
| CHEMBL248173 | — | — | 1 | 6.24 |
| CHEMBL391376 | — | — | 1 | 5.99 |
| CHEMBL395880 | — | — | 1 | 5.99 |
| CHEMBL429112 | — | — | 1 | 5.89 |
| CHEMBL240854 | — | — | 1 | 5.39 |
| CHEMBL240855 | — | — | 1 | 5.33 |
| CHEMBL442423 | — | — | 1 | - |
| CHEMBL248172 | — | — | 1 | - |
| CHEMBL392867 | — | — | 1 | - |
| CHEMBL247966 | — | — | 1 | - |
| CHEMBL241051 | — | — | 1 | - |
| CHEMBL393944 | — | — | 1 | - |
| CHEMBL428212 | — | — | 1 | - |
| CHEMBL247967 | — | — | 1 | - |
| CHEMBL395878 | — | — | 1 | - |
| CHEMBL395877 | — | — | 1 | - |
| CHEMBL240648 | — | — | 1 | - |
| CHEMBL438125 | — | — | 1 | - |
| CHEMBL240852 | — | — | 1 | - |
| CHEMBL240654 | — | — | 1 | - |
| CHEMBL427861 | — | — | 1 | - |
| CHEMBL240653 | — | — | 1 | - |
| CHEMBL241048 | — | — | 1 | - |
| CHEMBL240652 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240465 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL391288 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL240464 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL440048 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL248173 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL391376 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL395880 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL429112 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL240854 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL240855 | — | Ki | = | 4640.0 | nM | 5.33 |
| CHEMBL442423 | — | Ki | - | — | - | |
| CHEMBL248172 | — | Ki | > | 4040.0 | nM | - |
| CHEMBL392867 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL247966 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL241051 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL393944 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL428212 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL247967 | — | Ki | - | — | - | |
| CHEMBL395878 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL395877 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL240648 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL438125 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL240852 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL240654 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL427861 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL240653 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL241048 | — | Ki | > | 6020.0 | nM | - |
| CHEMBL240652 | — | Ki | > | 6020.0 | nM | - |