Assay Detail
Binding
CHEMBL902121
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Inhibition of MMP13
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.54 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391288 | — | — | 1 | 5.88 |
| CHEMBL248172 | — | — | 1 | 5.45 |
| CHEMBL429112 | — | — | 1 | 5.43 |
| CHEMBL248173 | — | — | 1 | 5.40 |
| CHEMBL442423 | — | — | 1 | - |
| CHEMBL241048 | — | — | 1 | - |
| CHEMBL391376 | — | — | 1 | - |
| CHEMBL392867 | — | — | 1 | - |
| CHEMBL247967 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391288 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL248172 | — | Ki | = | 3530.0 | nM | 5.45 |
| CHEMBL429112 | — | Ki | = | 3720.0 | nM | 5.43 |
| CHEMBL248173 | — | Ki | = | 3950.0 | nM | 5.40 |
| CHEMBL442423 | — | Ki | - | — | - | |
| CHEMBL241048 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL391376 | — | Ki | > | 5210.0 | nM | - |
| CHEMBL392867 | — | Ki | - | — | - | |
| CHEMBL247967 | — | Ki | - | — | - |