Assay Detail
Binding
CHEMBL902177
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Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in Amyloid beta-38 formation by LPECL assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H4 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.85 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218756 | — | — | 1 | 5.24 |
| CHEMBL392028 | — | — | 1 | 5.11 |
| CHEMBL385554 | — | — | 1 | 5.03 |
| CHEMBL248089 | — | — | 1 | 4.89 |
| CHEMBL396693 | — | — | 1 | 4.89 |
| CHEMBL248090 | — | — | 1 | 4.89 |
| CHEMBL392639 | — | — | 1 | 4.80 |
| CHEMBL247691 | — | — | 1 | 4.62 |
| CHEMBL247692 | — | — | 1 | 4.52 |
| CHEMBL247491 | — | — | 1 | 4.50 |
| CHEMBL247894 | — | — | 1 | - |
| CHEMBL247693 | — | — | 1 | - |
| CHEMBL247492 | — | — | 1 | - |
| CHEMBL247490 | — | — | 1 | - |
| CHEMBL396692 | — | — | 1 | - |
| CHEMBL438846 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218756 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL392028 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL385554 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL248089 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL396693 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL248090 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL392639 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL247691 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL247692 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL247491 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL247894 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL247693 | — | IC50 | - | — | - | |
| CHEMBL247492 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL247490 | — | IC50 | - | — | - | |
| CHEMBL396692 | — | IC50 | - | — | - | |
| CHEMBL438846 | — | IC50 | > | 40000.0 | nM | - |