Assay Detail
Binding
CHEMBL902320
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Inhibition of JNK1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.28 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437747 | — | — | 1 | 8.70 |
| CHEMBL424872 | — | — | 1 | 7.72 |
| CHEMBL374269 | — | — | 1 | 7.64 |
| CHEMBL377383 | — | — | 1 | 7.62 |
| CHEMBL391789 | — | — | 1 | 7.52 |
| CHEMBL241262 | — | — | 1 | 7.47 |
| CHEMBL240859 | — | — | 1 | 7.30 |
| CHEMBL240254 | — | — | 1 | 7.21 |
| CHEMBL219112 | — | — | 1 | 7.09 |
| CHEMBL375795 | — | — | 1 | 7.02 |
| CHEMBL391502 | — | — | 1 | 6.89 |
| CHEMBL239785 | — | — | 1 | 5.19 |
| CHEMBL391579 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437747 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL424872 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL374269 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL377383 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL391789 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL241262 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL240859 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL240254 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL219112 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL375795 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL391502 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL239785 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL391579 | — | IC50 | > | 10000.0 | nM | - |