Assay Detail
Binding
CHEMBL902495
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Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cells
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 6.88 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247058 | — | — | 1 | 8.26 |
| CHEMBL246637 | — | — | 1 | 8.16 |
| CHEMBL445102 | — | — | 1 | 7.95 |
| CHEMBL246439 | — | — | 1 | 7.81 |
| CHEMBL246643 | — | — | 1 | 7.68 |
| CHEMBL246644 | — | — | 1 | 7.68 |
| CHEMBL401031 | — | — | 1 | 7.62 |
| CHEMBL397770 | — | — | 1 | 7.58 |
| CHEMBL400827 | — | — | 1 | 7.53 |
| CHEMBL246854 | — | — | 1 | 7.27 |
| CHEMBL399396 | — | — | 1 | 7.23 |
| CHEMBL246231 | — | — | 1 | 7.22 |
| CHEMBL246438 | — | — | 1 | 7.17 |
| CHEMBL246021 | — | — | 1 | 7.08 |
| CHEMBL245615 | — | — | 1 | 7.01 |
| CHEMBL246848 | — | — | 1 | 6.97 |
| CHEMBL394065 | — | — | 1 | 6.92 |
| CHEMBL246849 | — | — | 1 | 6.90 |
| CHEMBL396092 | — | — | 1 | 6.89 |
| CHEMBL398368 | — | — | 1 | 6.80 |
| CHEMBL400826 | — | — | 1 | 6.78 |
| CHEMBL245614 | — | — | 1 | 6.75 |
| CHEMBL430198 | — | — | 1 | 6.74 |
| CHEMBL246855 | — | — | 1 | 6.73 |
| CHEMBL246230 | — | — | 1 | 6.70 |
| CHEMBL393027 | — | — | 1 | 6.70 |
| CHEMBL392822 | — | — | 1 | 6.42 |
| CHEMBL246642 | — | — | 1 | 6.36 |
| CHEMBL394066 | — | — | 1 | 6.26 |
| CHEMBL246020 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247058 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL246637 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL445102 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL246439 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL246643 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL246644 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL401031 | — | Ki | = | 23.9 | nM | 7.62 |
| CHEMBL397770 | — | Ki | = | 26.1 | nM | 7.58 |
| CHEMBL400827 | — | Ki | = | 29.6 | nM | 7.53 |
| CHEMBL246854 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL399396 | — | Ki | = | 58.8 | nM | 7.23 |
| CHEMBL246231 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL246438 | — | Ki | = | 68.1 | nM | 7.17 |
| CHEMBL246021 | — | Ki | = | 83.1 | nM | 7.08 |
| CHEMBL245615 | — | Ki | = | 98.4 | nM | 7.01 |
| CHEMBL246848 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL394065 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL246849 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL396092 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL398368 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL400826 | — | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL245614 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL430198 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL246855 | — | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL246230 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL393027 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL392822 | — | Ki | = | 382.0 | nM | 6.42 |
| CHEMBL246642 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL394066 | — | Ki | = | 548.0 | nM | 6.26 |
| CHEMBL246020 | — | Ki | = | 992.0 | nM | 6.00 |
| CHEMBL399601 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL246437 | — | Ki | = | 2370.0 | nM | 5.62 |
| CHEMBL245815 | — | Ki | = | 2890.0 | nM | 5.54 |
| CHEMBL245816 | — | Ki | = | 4265.0 | nM | 5.37 |
| CHEMBL392823 | — | Ki | = | 5360.0 | nM | 5.27 |
| CHEMBL246856 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL246232 | — | Ki | > | 10000.0 | nM | - |