Assay Detail
Binding
CHEMBL902496
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Displacement of [125I]IABN from human dopamine D4 receptor expressed in HEK293 cells
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.88 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL246438 | — | — | 1 | 7.47 |
| CHEMBL245615 | — | — | 1 | 6.89 |
| CHEMBL246854 | — | — | 1 | 6.82 |
| CHEMBL246643 | — | — | 1 | 6.78 |
| CHEMBL401031 | — | — | 1 | 6.50 |
| CHEMBL246021 | — | — | 1 | 6.46 |
| CHEMBL394065 | — | — | 1 | 6.44 |
| CHEMBL246644 | — | — | 1 | 6.39 |
| CHEMBL247058 | — | — | 1 | 6.25 |
| CHEMBL245614 | — | — | 1 | 6.17 |
| CHEMBL246642 | — | — | 1 | 6.17 |
| CHEMBL246637 | — | — | 1 | 5.96 |
| CHEMBL400826 | — | — | 1 | 5.92 |
| CHEMBL392823 | — | — | 1 | 5.87 |
| CHEMBL398368 | — | — | 1 | 5.83 |
| CHEMBL445102 | — | — | 1 | 5.82 |
| CHEMBL397770 | — | — | 1 | 5.81 |
| CHEMBL246437 | — | — | 1 | 5.71 |
| CHEMBL394066 | — | — | 1 | 5.67 |
| CHEMBL246230 | — | — | 1 | 5.64 |
| CHEMBL430198 | — | — | 1 | 5.64 |
| CHEMBL245816 | — | — | 1 | 5.61 |
| CHEMBL246020 | — | — | 1 | 5.56 |
| CHEMBL392822 | — | — | 1 | 5.55 |
| CHEMBL246439 | — | — | 1 | 5.52 |
| CHEMBL399396 | — | — | 1 | 5.45 |
| CHEMBL396092 | — | — | 1 | 5.45 |
| CHEMBL246848 | — | — | 1 | 5.43 |
| CHEMBL393027 | — | — | 1 | 5.41 |
| CHEMBL245815 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL246438 | — | Ki | = | 34.1 | nM | 7.47 |
| CHEMBL245615 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL246854 | — | Ki | = | 153.0 | nM | 6.82 |
| CHEMBL246643 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL401031 | — | Ki | = | 319.0 | nM | 6.50 |
| CHEMBL246021 | — | Ki | = | 348.0 | nM | 6.46 |
| CHEMBL394065 | — | Ki | = | 365.0 | nM | 6.44 |
| CHEMBL246644 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL247058 | — | Ki | = | 567.0 | nM | 6.25 |
| CHEMBL246642 | — | Ki | = | 677.0 | nM | 6.17 |
| CHEMBL245614 | — | Ki | = | 679.0 | nM | 6.17 |
| CHEMBL246637 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL400826 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL392823 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL398368 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL445102 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL397770 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL246437 | — | Ki | = | 1940.0 | nM | 5.71 |
| CHEMBL394066 | — | Ki | = | 2146.0 | nM | 5.67 |
| CHEMBL430198 | — | Ki | = | 2293.0 | nM | 5.64 |
| CHEMBL246230 | — | Ki | = | 2270.0 | nM | 5.64 |
| CHEMBL245816 | — | Ki | = | 2440.0 | nM | 5.61 |
| CHEMBL246020 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL392822 | — | Ki | = | 2820.0 | nM | 5.55 |
| CHEMBL246439 | — | Ki | = | 2990.0 | nM | 5.52 |
| CHEMBL399396 | — | Ki | = | 3520.0 | nM | 5.45 |
| CHEMBL396092 | — | Ki | = | 3540.0 | nM | 5.45 |
| CHEMBL246848 | — | Ki | = | 3750.0 | nM | 5.43 |
| CHEMBL393027 | — | Ki | = | 3870.0 | nM | 5.41 |
| CHEMBL246231 | — | Ki | = | 3930.0 | nM | 5.41 |
| CHEMBL245815 | — | Ki | = | 3930.0 | nM | 5.41 |
| CHEMBL399601 | — | Ki | = | 4450.0 | nM | 5.35 |
| CHEMBL400827 | — | Ki | = | 5140.0 | nM | 5.29 |
| CHEMBL246849 | — | Ki | = | 6090.0 | nM | 5.21 |
| CHEMBL246855 | — | Ki | = | 8890.0 | nM | 5.05 |
| CHEMBL246856 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL246232 | — | Ki | > | 20000.0 | nM | - |