Assay Detail
Binding
CHEMBL902547
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Inhibition of Lck
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.64 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247667 | — | — | 1 | 8.30 |
| CHEMBL247479 | — | — | 1 | 8.22 |
| CHEMBL247677 | — | — | 1 | 8.22 |
| CHEMBL399212 | — | — | 1 | 8.10 |
| CHEMBL247468 | — | — | 1 | 8.05 |
| CHEMBL247480 | — | — | 1 | 7.96 |
| CHEMBL247880 | — | — | 1 | 7.96 |
| CHEMBL247878 | — | — | 1 | 7.96 |
| CHEMBL248286 | — | — | 1 | 7.85 |
| CHEMBL247469 | — | — | 1 | 7.85 |
| CHEMBL394490 | — | — | 1 | 7.66 |
| CHEMBL248081 | — | — | 1 | 7.66 |
| CHEMBL248080 | — | — | 1 | 7.57 |
| CHEMBL247866 | — | — | 1 | 7.44 |
| CHEMBL248079 | — | — | 1 | 7.38 |
| CHEMBL247272 | — | — | 1 | 7.09 |
| CHEMBL399008 | — | — | 1 | 7.08 |
| CHEMBL247070 | — | — | 1 | 6.91 |
| CHEMBL247068 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247667 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL247479 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL247677 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL399212 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL247468 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL247480 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL247880 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL247878 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL248286 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL247469 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL394490 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL248081 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL248080 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL247866 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL248079 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL247272 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL399008 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL247070 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL247068 | — | IC50 | = | 1210.0 | nM | 5.92 |