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Assay Detail

CHEMBL902635

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.
Chen L, Wilson D, Jayaram HN, Pankiewicz KW.
J Med Chem (2007) 50 : 6685 -6691
PubMed 18038969 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 5.57 7.22
Activity 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL429090 1 7.22
CHEMBL98 VORINOSTAT 4.0 1 6.39
CHEMBL238461 MYCOPHENOLIC HYDROXAMIC ACID 1 5.30
CHEMBL392178 1 4.98
CHEMBL238904 1 4.85
CHEMBL238905 1 4.70
CHEMBL239105 1 -
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 -
CHEMBL394276 TIAZOFURIN ADENINE DINUCLEOTIDE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL429090 IC50 = 60.0 nM 7.22
CHEMBL98 VORINOSTAT IC50 = 410.0 nM 6.39
CHEMBL238461 MYCOPHENOLIC HYDROXAMIC ACID IC50 = 5000.0 nM 5.30
CHEMBL392178 IC50 = 10400.0 nM 4.98
CHEMBL238904 IC50 = 14000.0 nM 4.85
CHEMBL238905 IC50 = 20100.0 nM 4.70
CHEMBL239105 IC50 > 100000.0 nM -
CHEMBL866 MYCOPHENOLIC ACID Activity - -
CHEMBL394276 TIAZOFURIN ADENINE DINUCLEOTIDE Activity - -