Assay Detail
Functional
CHEMBL902636
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Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.13 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429090 | — | — | 1 | 6.54 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.12 |
| CHEMBL238461 | MYCOPHENOLIC HYDROXAMIC ACID | — | 1 | 5.32 |
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 5.11 |
| CHEMBL392178 | — | — | 1 | 4.97 |
| CHEMBL238904 | — | — | 1 | 4.37 |
| CHEMBL238905 | — | — | 1 | 4.35 |
| CHEMBL239105 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429090 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL238461 | MYCOPHENOLIC HYDROXAMIC ACID | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL866 | MYCOPHENOLIC ACID | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL392178 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL238904 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL238905 | — | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL239105 | — | IC50 | = | 60000.0 | nM | 4.22 |