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Assay Detail

CHEMBL902660

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Photocytotoxicity against UV irradiated human LoVo cells after 24 hrs by MTT assay
10
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LoVo
Confidence 1 — Organism
Curated By Autocuration

Target

LoVo (CHEMBL614721)
Type CELL-LINE
Organism Homo sapiens

Publication

BINOL-amino acid conjugates as triggerable carriers of DNA-targeted potent photocytotoxic agents.
Doria F, Richter SN, Nadai M, Colloredo-Mels S, Mella M, Palumbo M, Freccero M.
J Med Chem (2007) 50 : 6570 -6579
PubMed 18047263 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 6.32 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL393687 1 6.89
CHEMBL391523 2 6.66
CHEMBL1475 TRIOXSALEN 4.0 1 6.03
CHEMBL451186 1 5.40
CHEMBL391771 1 -
CHEMBL394048 2 -
CHEMBL241562 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL393687 EC50 = 130.0 nM 6.89
CHEMBL391523 EC50 = 220.0 nM 6.66
CHEMBL391523 EC50 = 230.0 nM 6.64
CHEMBL1475 TRIOXSALEN EC50 = 940.0 nM 6.03
CHEMBL451186 EC50 = 4000.0 nM 5.40
CHEMBL391771 EC50 > 200000.0 nM -
CHEMBL394048 EC50 > 200000.0 nM -
CHEMBL241562 EC50 > 200000.0 nM -
CHEMBL241562 EC50 > 200000.0 nM -
CHEMBL394048 EC50 > 200000.0 nM -