Assay Detail
Binding
CHEMBL903360
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Inhibition of human recombinant caspase 7
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.61 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248508 | — | — | 1 | 8.10 |
| CHEMBL248310 | — | — | 1 | 7.19 |
| CHEMBL180623 | — | — | 1 | 6.85 |
| CHEMBL248309 | — | — | 1 | 6.55 |
| CHEMBL246887 | — | — | 1 | 6.10 |
| CHEMBL392245 | — | — | 1 | 6.04 |
| CHEMBL396625 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248508 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL248310 | — | IC50 | = | 64.7 | nM | 7.19 |
| CHEMBL180623 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL248309 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL246887 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL392245 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL396625 | — | IC50 | = | 3490.0 | nM | 5.46 |