Assay Detail
Binding
CHEMBL903376
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Inhibition of Pim1 kinase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.87 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391586 | — | — | 1 | 7.30 |
| CHEMBL246457 | — | — | 1 | 6.47 |
| CHEMBL246458 | — | — | 1 | 6.43 |
| CHEMBL393238 | — | — | 1 | 6.37 |
| CHEMBL246656 | — | — | 1 | 6.04 |
| CHEMBL246661 | — | — | 1 | 5.99 |
| CHEMBL246663 | — | — | 1 | 5.94 |
| CHEMBL246657 | — | — | 1 | 5.91 |
| CHEMBL397641 | — | — | 1 | 5.75 |
| CHEMBL246655 | — | — | 1 | 5.36 |
| CHEMBL247682 | — | — | 1 | 5.32 |
| CHEMBL247684 | — | — | 1 | 4.70 |
| CHEMBL427876 | — | — | 1 | 4.70 |
| CHEMBL248091 | — | — | 1 | - |
| CHEMBL395464 | — | — | 1 | - |
| CHEMBL247681 | — | — | 1 | - |
| CHEMBL391154 | — | — | 1 | - |
| CHEMBL247077 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391586 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL246457 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL246458 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL393238 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL246656 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL246661 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL246663 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL246657 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL397641 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL246655 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL247682 | — | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL247684 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL427876 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL248091 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL395464 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL247681 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL391154 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL247077 | — | IC50 | > | 20000.0 | nM | - |