Assay Detail
Binding
CHEMBL903409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium- and chloride-dependent glycine transporter 2 (CHEMBL3060) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A novel, non-substrate-based series of glycine type 1 transporter inhibitors derived from high-throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.53 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239601 | — | — | 1 | 7.50 |
| CHEMBL239603 | — | — | 1 | 6.50 |
| CHEMBL394236 | — | — | 1 | 6.42 |
| CHEMBL239605 | — | — | 1 | 6.40 |
| CHEMBL393168 | — | — | 1 | 6.28 |
| CHEMBL392350 | — | — | 1 | 6.07 |
| CHEMBL392586 | — | — | 1 | - |
| CHEMBL393169 | — | — | 1 | - |
| CHEMBL392770 | — | — | 1 | - |
| CHEMBL239598 | — | — | 1 | - |
| CHEMBL239596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239601 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL239603 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL394236 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL239605 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL393168 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL392350 | — | IC50 | = | 857.0 | nM | 6.07 |
| CHEMBL392586 | — | IC50 | - | — | - | |
| CHEMBL393169 | — | IC50 | - | — | - | |
| CHEMBL392770 | — | IC50 | - | — | - | |
| CHEMBL239598 | — | IC50 | - | — | - | |
| CHEMBL239596 | — | IC50 | - | — | - |