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Assay Detail

CHEMBL903456

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Binding
Inhibition of HCV NS5B RdRp
ChEMBL ↗
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors.
Rong F, Chow S, Yan S, Larson G, Hong Z, Wu J.
Bioorg Med Chem Lett (2007) 17 : 1663 -1666
PubMed 17258458 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 55 5.20 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL241530 — — 1 6.22
CHEMBL245437 — — 1 6.16
CHEMBL395470 — — 1 5.92
CHEMBL264032 — — 1 5.89
CHEMBL239588 — — 1 5.89
CHEMBL391898 — — 1 5.89
CHEMBL392338 — — 1 5.80
CHEMBL239382 — — 1 5.80
CHEMBL273563 — — 1 5.77
CHEMBL392119 — — 1 5.75
CHEMBL239187 — — 1 5.75
CHEMBL394730 — — 1 5.72
CHEMBL245436 — — 1 5.66
CHEMBL395466 — — 1 5.50
CHEMBL239381 — — 1 5.47
CHEMBL248308 — — 1 5.43
CHEMBL263615 — — 1 5.39
CHEMBL239582 — — 1 5.39
CHEMBL245418 — — 1 5.34
CHEMBL241727 — — 1 5.34
CHEMBL239188 — — 1 5.30
CHEMBL245438 — — 1 5.29
CHEMBL246242 — — 1 5.26
CHEMBL248146 — — 1 5.26
CHEMBL239589 — — 1 5.21
CHEMBL398049 — — 1 5.07
CHEMBL245817 — — 1 4.96
CHEMBL399009 — — 1 4.82
CHEMBL247287 — — 1 4.82
CHEMBL436994 — — 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL241530 — IC50 = 600.0 nM 6.22
CHEMBL245437 — IC50 = 690.0 nM 6.16
CHEMBL395470 — IC50 = 1200.0 nM 5.92
CHEMBL264032 — IC50 = 1300.0 nM 5.89
CHEMBL239588 — IC50 = 1300.0 nM 5.89
CHEMBL391898 — IC50 = 1300.0 nM 5.89
CHEMBL392338 — IC50 = 1600.0 nM 5.80
CHEMBL239382 — IC50 = 1600.0 nM 5.80
CHEMBL273563 — IC50 = 1700.0 nM 5.77
CHEMBL392119 — IC50 = 1800.0 nM 5.75
CHEMBL239187 — IC50 = 1800.0 nM 5.75
CHEMBL394730 — IC50 = 1900.0 nM 5.72
CHEMBL245436 — IC50 = 2200.0 nM 5.66
CHEMBL395466 — IC50 = 3200.0 nM 5.50
CHEMBL239381 — IC50 = 3400.0 nM 5.47
CHEMBL248308 — IC50 = 3700.0 nM 5.43
CHEMBL263615 — IC50 = 4100.0 nM 5.39
CHEMBL239582 — IC50 = 4100.0 nM 5.39
CHEMBL245418 — IC50 = 4600.0 nM 5.34
CHEMBL241727 — IC50 = 4600.0 nM 5.34
CHEMBL239188 — IC50 = 5000.0 nM 5.30
CHEMBL245438 — IC50 = 5100.0 nM 5.29
CHEMBL246242 — IC50 = 5500.0 nM 5.26
CHEMBL248146 — IC50 = 5500.0 nM 5.26
CHEMBL239589 — IC50 = 6100.0 nM 5.21
CHEMBL398049 — IC50 = 8600.0 nM 5.07
CHEMBL245817 — IC50 = 11000.0 nM 4.96
CHEMBL399009 — IC50 = 15000.0 nM 4.82
CHEMBL247287 — IC50 = 15000.0 nM 4.82
CHEMBL436994 — IC50 = 16000.0 nM 4.80
CHEMBL246446 — IC50 = 17000.0 nM 4.77
CHEMBL248103 — IC50 = 17000.0 nM 4.77
CHEMBL245617 — IC50 = 26000.0 nM 4.58
CHEMBL247069 — IC50 = 33000.0 nM 4.48
CHEMBL395278 — IC50 = 37000.0 nM 4.43
CHEMBL246448 — IC50 = 40000.0 nM 4.40
CHEMBL245818 — IC50 = 49000.0 nM 4.31
CHEMBL398048 — IC50 = 53000.0 nM 4.28
CHEMBL248278 — IC50 = 72000.0 nM 4.14
CHEMBL246447 — IC50 = 79000.0 nM 4.10
CHEMBL396626 — IC50 = 100000.0 nM 4.00
CHEMBL412246 — IC50 > 100000.0 nM -
CHEMBL395469 — IC50 > 100000.0 nM -
CHEMBL437759 — IC50 > 100000.0 nM -
CHEMBL246864 — IC50 > 100000.0 nM -
CHEMBL246865 — IC50 > 100000.0 nM -
CHEMBL401033 — IC50 > 100000.0 nM -
CHEMBL443582 — IC50 > 100000.0 nM -
CHEMBL441163 — IC50 - — -
CHEMBL248485 — IC50 > 100000.0 nM -