Assay Detail
Toxicity
CHEMBL903477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.77 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442272 | — | — | 1 | 5.96 |
| CHEMBL246519 | — | — | 1 | 5.92 |
| CHEMBL245492 | — | — | 1 | 5.80 |
| CHEMBL397392 | — | — | 1 | 5.62 |
| CHEMBL391143 | — | — | 1 | 5.54 |
| CHEMBL247340 | — | — | 1 | - |
| CHEMBL245687 | — | — | 1 | - |
| CHEMBL247538 | — | — | 1 | - |
| CHEMBL247341 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442272 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL246519 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL245492 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL397392 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL391143 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL247340 | — | IC50 | - | — | - | |
| CHEMBL245687 | — | IC50 | - | — | - | |
| CHEMBL247538 | — | IC50 | - | — | - | |
| CHEMBL247341 | — | IC50 | - | — | - |