Assay Detail
Binding
CHEMBL903630
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Inhibition of human telomerase by TRAP assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.50 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397746 | — | — | 1 | 7.52 |
| CHEMBL336434 | — | — | 1 | 6.92 |
| CHEMBL239793 | — | — | 1 | 6.64 |
| CHEMBL397768 | — | — | 1 | 6.62 |
| CHEMBL397767 | — | — | 1 | 6.46 |
| CHEMBL396326 | — | — | 1 | 6.44 |
| CHEMBL396113 | — | — | 1 | 6.41 |
| CHEMBL396325 | — | — | 1 | 6.36 |
| CHEMBL1162066 | — | — | 1 | 6.07 |
| CHEMBL239791 | — | — | 1 | 6.06 |
| CHEMBL239789 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397746 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL336434 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL239793 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL397768 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL397767 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL396326 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL396113 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL396325 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1162066 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL239791 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL239789 | — | EC50 | = | 1000.0 | nM | 6.00 |