Assay Detail
Functional
CHEMBL903632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MCF7 cells by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.00 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396325 | — | — | 1 | 6.70 |
| CHEMBL239793 | — | — | 1 | 6.34 |
| CHEMBL239791 | — | — | 1 | 6.28 |
| CHEMBL396326 | — | — | 1 | 6.27 |
| CHEMBL396113 | — | — | 1 | 6.24 |
| CHEMBL397768 | — | — | 1 | 6.00 |
| CHEMBL1162066 | — | — | 1 | 5.97 |
| CHEMBL397746 | — | — | 1 | 5.65 |
| CHEMBL336434 | — | — | 1 | 5.60 |
| CHEMBL239789 | — | — | 1 | 5.52 |
| CHEMBL397767 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396325 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL239793 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL239791 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL396326 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL396113 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL397768 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1162066 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL397746 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL336434 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL239789 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL397767 | — | IC50 | = | 3720.0 | nM | 5.43 |