Assay Detail
ADMET
CHEMBL903668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PBMC after 6 days
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.09 | 4.09 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226485 | — | — | 1 | 4.09 |
| CHEMBL389930 | — | — | 1 | 4.08 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL19977 | — | — | 1 | - |
| CHEMBL226490 | — | — | 1 | - |
| CHEMBL375484 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226485 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL389930 | — | IC50 | = | 83500.0 | nM | 4.08 |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL19977 | — | Activity | - | — | - | |
| CHEMBL226490 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL375484 | — | IC50 | > | 100000.0 | nM | - |