Assay Detail
Binding
CHEMBL903949
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.01 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226390 | — | — | 1 | 6.66 |
| CHEMBL228077 | — | — | 1 | 6.48 |
| CHEMBL226447 | — | — | 1 | 6.33 |
| CHEMBL375943 | — | — | 1 | 6.32 |
| CHEMBL375895 | — | — | 1 | 6.21 |
| CHEMBL376145 | — | — | 1 | 5.97 |
| CHEMBL226448 | — | — | 1 | 5.96 |
| CHEMBL226445 | — | — | 1 | 5.75 |
| CHEMBL226499 | — | — | 1 | 5.65 |
| CHEMBL375056 | — | — | 1 | 5.62 |
| CHEMBL226446 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226390 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL228077 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL226447 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL375943 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL375895 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL376145 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL226448 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL226445 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL226499 | — | Ki | = | 2260.0 | nM | 5.65 |
| CHEMBL375056 | — | Ki | = | 2380.0 | nM | 5.62 |
| CHEMBL226446 | — | Ki | = | 7620.0 | nM | 5.12 |