Assay Detail
Binding
CHEMBL904079
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Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.66 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL226149 | — | — | 1 | 5.17 |
| CHEMBL388309 | — | — | 1 | 5.16 |
| CHEMBL228231 | — | — | 1 | 5.15 |
| CHEMBL227565 | — | — | 1 | 5.13 |
| CHEMBL228230 | — | — | 1 | 5.12 |
| CHEMBL226438 | — | — | 1 | 5.12 |
| CHEMBL227567 | — | — | 1 | 5.11 |
| CHEMBL514138 | CGS-27023A | — | 1 | 5.11 |
| CHEMBL228176 | — | — | 1 | 5.06 |
| CHEMBL227566 | — | — | 1 | 5.06 |
| CHEMBL376841 | — | — | 1 | 5.05 |
| CHEMBL388982 | — | — | 1 | 5.04 |
| CHEMBL228229 | — | — | 1 | 5.04 |
| CHEMBL442057 | — | — | 1 | 5.03 |
| CHEMBL373721 | — | — | 1 | 5.03 |
| CHEMBL226439 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL226149 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL388309 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL228231 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL227565 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL228230 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL226438 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL227567 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL514138 | CGS-27023A | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL228176 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL227566 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL376841 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL388982 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL228229 | — | Ki | = | 9200.0 | nM | 5.04 |
| CHEMBL442057 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL373721 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL226439 | — | Ki | = | 9500.0 | nM | 5.02 |