Assay Detail
Binding
CHEMBL904080
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Inhibition of human recombinant MMP2 expressed in mouse myeloma cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.34 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | — | 1 | 7.60 |
| CHEMBL442057 | — | — | 1 | 6.18 |
| CHEMBL388982 | — | — | 1 | 6.14 |
| CHEMBL226438 | — | — | 1 | 5.97 |
| CHEMBL373721 | — | — | 1 | 5.82 |
| CHEMBL227567 | — | — | 1 | 5.70 |
| CHEMBL228176 | — | — | 1 | 5.68 |
| CHEMBL226439 | — | — | 1 | 5.31 |
| CHEMBL376841 | — | — | 1 | 5.02 |
| CHEMBL227565 | — | — | 1 | 4.52 |
| CHEMBL228230 | — | — | 1 | 4.47 |
| CHEMBL228229 | — | — | 1 | 4.17 |
| CHEMBL388309 | — | — | 1 | 4.09 |
| CHEMBL226149 | — | — | 1 | 4.03 |
| CHEMBL228231 | — | — | 1 | - |
| CHEMBL227566 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL442057 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL388982 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL226438 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL373721 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL227567 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL228176 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL226439 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL376841 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL227565 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL228230 | — | IC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL228229 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL388309 | — | IC50 | = | 81800.0 | nM | 4.09 |
| CHEMBL226149 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL228231 | — | IC50 | = | 151000.0 | nM | - |
| CHEMBL227566 | — | IC50 | = | 137000.0 | nM | - |