Assay Detail
Binding
CHEMBL904136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]flumazenil from bovine brain cortex GABAA/Bz receptor
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 7.50 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228342 | — | — | 1 | 9.10 |
| CHEMBL229145 | — | — | 1 | 8.77 |
| CHEMBL229144 | — | — | 1 | 8.32 |
| CHEMBL228288 | — | — | 1 | 8.27 |
| CHEMBL390950 | — | — | 1 | 8.19 |
| CHEMBL228290 | — | — | 1 | 8.12 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 8.00 |
| CHEMBL389391 | — | — | 1 | 7.92 |
| CHEMBL229143 | — | — | 1 | 7.92 |
| CHEMBL229198 | — | — | 1 | 7.87 |
| CHEMBL229901 | — | — | 1 | 7.85 |
| CHEMBL229142 | — | — | 1 | 7.85 |
| CHEMBL229928 | — | — | 1 | 7.81 |
| CHEMBL390165 | — | — | 1 | 7.80 |
| CHEMBL388601 | — | — | 1 | 7.75 |
| CHEMBL229900 | — | — | 1 | 7.64 |
| CHEMBL228287 | — | — | 1 | 7.43 |
| CHEMBL376329 | — | — | 1 | 7.43 |
| CHEMBL228395 | — | — | 1 | 7.38 |
| CHEMBL229848 | — | — | 1 | 7.27 |
| CHEMBL443057 | — | — | 1 | 7.21 |
| CHEMBL376123 | — | — | 1 | 7.14 |
| CHEMBL376124 | — | — | 1 | 7.09 |
| CHEMBL229847 | — | — | 1 | 6.92 |
| CHEMBL229846 | — | — | 1 | 6.80 |
| CHEMBL229845 | — | — | 1 | 6.71 |
| CHEMBL229897 | — | — | 1 | 6.70 |
| CHEMBL228291 | — | — | 1 | 6.63 |
| CHEMBL229896 | — | — | 1 | 6.48 |
| CHEMBL229133 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228342 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL229145 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL229144 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL228288 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL390950 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL228290 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL12 | DIAZEPAM | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL389391 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL229143 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL229198 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL229901 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL229142 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL229928 | — | Ki | = | 15.6 | nM | 7.81 |
| CHEMBL390165 | — | Ki | = | 15.8 | nM | 7.80 |
| CHEMBL388601 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL229900 | — | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL228287 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL376329 | — | Ki | = | 36.9 | nM | 7.43 |
| CHEMBL228395 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL229848 | — | Ki | = | 53.2 | nM | 7.27 |
| CHEMBL443057 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL376123 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL376124 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL229847 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL229846 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL229845 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL229897 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL228291 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL229896 | — | Ki | = | 332.0 | nM | 6.48 |
| CHEMBL229133 | — | Ki | = | 374.0 | nM | 6.43 |
| CHEMBL229196 | — | Ki | = | 1700.0 | nM | 5.77 |