Assay Detail
Binding
CHEMBL904249
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Inhibition of GST-p300 HAT assessed as histone acetylation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.70 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222328 | — | — | 1 | 5.30 |
| CHEMBL222573 | — | — | 1 | 4.68 |
| CHEMBL221782 | — | — | 1 | 4.48 |
| CHEMBL129964 | — | — | 1 | 4.34 |
| CHEMBL222543 | — | — | 1 | - |
| CHEMBL129148 | — | — | 1 | - |
| CHEMBL17205 | CYCLOVALONE | 2.0 | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222328 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL222573 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL221782 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL129964 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL222543 | — | IC50 | = | 168000.0 | nM | - |
| CHEMBL129148 | — | IC50 | = | 233000.0 | nM | - |
| CHEMBL17205 | CYCLOVALONE | IC50 | = | 111000.0 | nM | - |
| CHEMBL140 | CURCUMIN | IC50 | > | 400000.0 | nM | - |