Assay Detail
Binding
CHEMBL904425
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Inhibition of human TF/FVIIa complex by chromogenic assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.78 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224485 | — | — | 1 | 7.05 |
| CHEMBL376806 | — | — | 1 | 6.82 |
| CHEMBL388161 | — | — | 1 | 6.75 |
| CHEMBL225450 | — | — | 1 | 6.52 |
| CHEMBL225501 | — | — | 1 | 6.52 |
| CHEMBL426187 | — | — | 1 | 6.23 |
| CHEMBL375051 | — | — | 1 | 6.16 |
| CHEMBL376187 | — | — | 1 | 6.07 |
| CHEMBL389006 | — | — | 1 | 5.89 |
| CHEMBL441714 | — | — | 1 | 5.66 |
| CHEMBL224925 | — | — | 1 | 5.62 |
| CHEMBL389191 | — | — | 1 | 5.50 |
| CHEMBL388402 | — | — | 1 | 5.38 |
| CHEMBL225185 | — | — | 1 | 5.38 |
| CHEMBL374175 | — | — | 1 | 5.07 |
| CHEMBL390784 | — | — | 1 | 4.72 |
| CHEMBL225322 | — | — | 1 | 4.72 |
| CHEMBL376188 | — | — | 1 | 4.04 |
| CHEMBL225130 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224485 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL376806 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL388161 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL225450 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL225501 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL426187 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL375051 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL376187 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL389006 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL441714 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL224925 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL389191 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL388402 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL225185 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL374175 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL390784 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL225322 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL376188 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL225130 | — | IC50 | = | 191000.0 | nM | - |