Assay Detail
Binding
CHEMBL904571
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Inhibition of human GST-Cdc25A expressed in Escherichia coli BL21(DE3)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.99 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228420 | — | — | 1 | 5.35 |
| CHEMBL389865 | — | — | 1 | 5.33 |
| CHEMBL228419 | — | — | 1 | 5.29 |
| CHEMBL228418 | — | — | 1 | 5.20 |
| CHEMBL228410 | — | — | 1 | 5.09 |
| CHEMBL228358 | — | — | 1 | 4.35 |
| CHEMBL376172 | — | — | 1 | 4.35 |
| CHEMBL228356 | — | — | 1 | - |
| CHEMBL375036 | — | — | 1 | - |
| CHEMBL228357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228420 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL389865 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL228419 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL228418 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL228410 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL228358 | — | IC50 | = | 44400.0 | nM | 4.35 |
| CHEMBL376172 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL228356 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL375036 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL228357 | — | IC50 | > | 100000.0 | nM | - |