Assay Detail
Binding
CHEMBL904692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from human A2B receptor expressed in HEK293 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.36 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226238 | — | — | 1 | 7.80 |
| CHEMBL375293 | — | — | 1 | 7.77 |
| CHEMBL225972 | — | — | 1 | 7.62 |
| CHEMBL438306 | — | — | 1 | 7.55 |
| CHEMBL390600 | — | — | 1 | 7.47 |
| CHEMBL226236 | — | — | 1 | 7.41 |
| CHEMBL226237 | — | — | 1 | 7.16 |
| CHEMBL389040 | — | — | 1 | 6.94 |
| CHEMBL226188 | — | — | 1 | 6.94 |
| CHEMBL225982 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226238 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL375293 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL225972 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL438306 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL390600 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL226236 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL226237 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL389040 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL226188 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL225982 | — | Ki | = | 119.0 | nM | 6.92 |