Assay Detail
Binding
CHEMBL904788
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MK2
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
MAP kinase-activated protein kinase 2 (CHEMBL2208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.30 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388853 | — | — | 1 | 8.10 |
| CHEMBL388530 | — | — | 1 | 8.10 |
| CHEMBL226403 | — | — | 1 | 8.07 |
| CHEMBL226206 | — | — | 1 | 7.82 |
| CHEMBL226261 | — | — | 1 | 7.77 |
| CHEMBL374177 | — | — | 1 | 7.68 |
| CHEMBL389658 | — | — | 1 | 7.66 |
| CHEMBL388619 | — | — | 1 | 7.60 |
| CHEMBL226472 | — | — | 1 | 7.52 |
| CHEMBL226351 | — | — | 1 | 7.52 |
| CHEMBL226470 | — | — | 1 | 7.50 |
| CHEMBL226420 | — | — | 1 | 7.43 |
| CHEMBL226475 | — | — | 1 | 7.39 |
| CHEMBL226321 | — | — | 1 | 7.34 |
| CHEMBL225975 | — | — | 1 | 7.32 |
| CHEMBL388307 | — | — | 1 | 7.30 |
| CHEMBL226424 | — | — | 1 | 7.29 |
| CHEMBL226350 | — | — | 1 | 7.28 |
| CHEMBL226474 | — | — | 1 | 7.26 |
| CHEMBL376384 | — | — | 1 | 7.25 |
| CHEMBL225973 | — | — | 1 | 7.25 |
| CHEMBL389657 | — | — | 1 | 7.21 |
| CHEMBL388566 | — | — | 1 | 7.18 |
| CHEMBL388391 | — | — | 1 | 7.12 |
| CHEMBL390601 | — | — | 1 | 7.08 |
| CHEMBL226471 | — | — | 1 | 6.90 |
| CHEMBL225519 | — | — | 1 | 6.77 |
| CHEMBL226369 | — | — | 1 | 6.77 |
| CHEMBL226405 | — | — | 1 | 6.39 |
| CHEMBL426001 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388853 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL388530 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL226403 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL226206 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL226261 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL374177 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL389658 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL388619 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL226472 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL226351 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL226470 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL226420 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL226475 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL226321 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL225975 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL388307 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL226424 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL226350 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL226474 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL376384 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL225973 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL389657 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL388566 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL388391 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL390601 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL226471 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL225519 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL226369 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL226405 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL426001 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL226232 | — | IC50 | = | 608.0 | nM | 6.22 |