Assay Detail
Functional
CHEMBL904789
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Inhibition of TNFalpha production in U937 cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.06 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388566 | — | — | 1 | 5.85 |
| CHEMBL226474 | — | — | 1 | 5.66 |
| CHEMBL388307 | — | — | 1 | 5.62 |
| CHEMBL226470 | — | — | 1 | 5.57 |
| CHEMBL226369 | — | — | 1 | 5.42 |
| CHEMBL226350 | — | — | 1 | 5.38 |
| CHEMBL226403 | — | — | 1 | 5.36 |
| CHEMBL226420 | — | — | 1 | 5.34 |
| CHEMBL226471 | — | — | 1 | 5.32 |
| CHEMBL226351 | — | — | 1 | 5.24 |
| CHEMBL388391 | — | — | 1 | 5.17 |
| CHEMBL226472 | — | — | 1 | 5.13 |
| CHEMBL426001 | — | — | 1 | 5.05 |
| CHEMBL225975 | — | — | 1 | 5.00 |
| CHEMBL226261 | — | — | 1 | 5.00 |
| CHEMBL226321 | — | — | 1 | 4.96 |
| CHEMBL226475 | — | — | 1 | 4.92 |
| CHEMBL376384 | — | — | 1 | 4.82 |
| CHEMBL226424 | — | — | 1 | 4.75 |
| CHEMBL225519 | — | — | 1 | 4.72 |
| CHEMBL388530 | — | — | 1 | 4.70 |
| CHEMBL388853 | — | — | 1 | 4.64 |
| CHEMBL225973 | — | — | 1 | 4.64 |
| CHEMBL374177 | — | — | 1 | 4.46 |
| CHEMBL388619 | — | — | 1 | 4.44 |
| CHEMBL226405 | — | — | 1 | 4.33 |
| CHEMBL226206 | — | — | 1 | - |
| CHEMBL390601 | — | — | 1 | - |
| CHEMBL389658 | — | — | 1 | - |
| CHEMBL389657 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388566 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL226474 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL388307 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL226470 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL226369 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL226350 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL226403 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL226420 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL226471 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL226351 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL388391 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL226472 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL426001 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL225975 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL226261 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL226321 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL226475 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL376384 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL226424 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL225519 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL388530 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL388853 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL225973 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL374177 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL388619 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL226405 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL226206 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL390601 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL389658 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL389657 | — | IC50 | > | 100000.0 | nM | - |