Assay Detail
Binding
CHEMBL904791
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MK5
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
MAP kinase-activated protein kinase 5 (CHEMBL3094) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.73 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226403 | — | — | 1 | 7.09 |
| CHEMBL388566 | — | — | 1 | 6.85 |
| CHEMBL226471 | — | — | 1 | 6.68 |
| CHEMBL225519 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226403 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL388566 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL226471 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL225519 | — | IC50 | = | 500.0 | nM | 6.30 |