Assay Detail
Binding
CHEMBL904817
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Inhibition of NADH-ubiquinone oxidoreductase assessed by NADH oxidase activity in beef heart submitochondrial particles
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New antitumoral acetogenin 'Guanacone type' derivatives: isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.73 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267735 | — | — | 1 | 9.40 |
| CHEMBL145624 | GUANACONE | — | 1 | 8.92 |
| CHEMBL267383 | — | — | 1 | 8.55 |
| CHEMBL225674 | — | — | 1 | 8.47 |
| CHEMBL429023 | ROTENONE | — | 1 | 8.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267735 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL145624 | GUANACONE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL267383 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL225674 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL429023 | ROTENONE | IC50 | = | 5.1 | nM | 8.29 |