Assay Detail
ADMET
CHEMBL904861
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Antiproliferative activity against human RPTEC
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | RPTEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.15 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.00 |
| CHEMBL389164 | — | — | 1 | 6.82 |
| CHEMBL557165 | — | — | 1 | 6.22 |
| CHEMBL229943 | — | — | 1 | 5.89 |
| CHEMBL229577 | — | — | 1 | 5.64 |
| CHEMBL229891 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL389164 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL557165 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL229943 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL229577 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL229891 | — | IC50 | = | 5000.0 | nM | 5.30 |