Assay Detail
Binding
CHEMBL904865
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Binding affinity to human recombinant HSP90 assessed as inhibition of biotinylated-geldanamycin binding
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.94 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.16 |
| CHEMBL229839 | — | — | 1 | 6.10 |
| CHEMBL557165 | — | — | 1 | 6.05 |
| CHEMBL536072 | — | — | 1 | 6.05 |
| CHEMBL376166 | — | — | 1 | 6.05 |
| CHEMBL112953 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL229839 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL557165 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL536072 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL376166 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL112953 | — | IC50 | = | 6000.0 | nM | 5.22 |