Assay Detail
Binding
CHEMBL904867
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Binding affinity to HSP90 in human NDF cell lysates assessed as inhibition of biotinylated-geldanamycin binding
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NDF |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.85 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557165 | — | — | 1 | 6.40 |
| CHEMBL229943 | — | — | 1 | 6.10 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.00 |
| CHEMBL389164 | — | — | 1 | 6.00 |
| CHEMBL112953 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557165 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL229943 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL389164 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL112953 | — | IC50 | = | 18000.0 | nM | 4.75 |