Assay Detail
Functional
CHEMBL904869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Selectivity index, ratio of IC50 for human RPTEC cells to IC50 for HT29 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPTEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.95 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557165 | — | — | 1 | 5.30 |
| CHEMBL389164 | — | — | 1 | 5.16 |
| CHEMBL229943 | — | — | 1 | 5.00 |
| CHEMBL229891 | — | — | 1 | 5.00 |
| CHEMBL229577 | — | — | 1 | 4.92 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557165 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL389164 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL229943 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL229891 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL229577 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 50000.0 | nM | 4.30 |