Assay Detail
Functional
CHEMBL904900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of P-gp-mediated multidrug resistance to Cytotoxicity of colchicine against human KB-3-1 cells at 5 uM after 68 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Reversal of P-glycoprotein-mediated multidrug resistance by sipholane triterpenoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.23 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 8.33 |
| CHEMBL226093 | SIPHOLENOL A | — | 1 | 8.30 |
| CHEMBL226197 | — | — | 1 | 8.30 |
| CHEMBL226142 | SIPHOLENONE A | — | 1 | 8.28 |
| CHEMBL226247 | — | — | 1 | 8.25 |
| CHEMBL388091 | 28-HYDROXYSIPHOLENOL A | — | 1 | 8.23 |
| CHEMBL226248 | — | — | 1 | 8.20 |
| CHEMBL226143 | SIPHONELLINOL C | — | 1 | 8.11 |
| CHEMBL388090 | SIPHOLENOL I | — | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL226093 | SIPHOLENOL A | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL226197 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL226142 | SIPHOLENONE A | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL226247 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL388091 | 28-HYDROXYSIPHOLENOL A | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL226248 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL226143 | SIPHONELLINOL C | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL388090 | SIPHOLENOL I | IC50 | = | 8.6 | nM | 8.07 |