Assay Detail
Functional
CHEMBL904901
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Reversal of P-gp-mediated multidrug resistance to Cytotoxicity of colchicine against human KB-C2 cells at 5 uM after 68 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-C2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Reversal of P-glycoprotein-mediated multidrug resistance by sipholane triterpenoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.81 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 7.00 |
| CHEMBL226093 | SIPHOLENOL A | — | 1 | 6.68 |
| CHEMBL226142 | SIPHOLENONE A | — | 1 | 6.03 |
| CHEMBL226143 | SIPHONELLINOL C | — | 1 | 5.83 |
| CHEMBL226197 | — | — | 1 | 5.54 |
| CHEMBL388090 | SIPHOLENOL I | — | 1 | 5.54 |
| CHEMBL388091 | 28-HYDROXYSIPHOLENOL A | — | 1 | 5.29 |
| CHEMBL226248 | — | — | 1 | 5.22 |
| CHEMBL226247 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL226093 | SIPHOLENOL A | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL226142 | SIPHOLENONE A | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL226143 | SIPHONELLINOL C | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL226197 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL388090 | SIPHOLENOL I | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL388091 | 28-HYDROXYSIPHOLENOL A | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL226248 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL226247 | — | IC50 | = | 6320.0 | nM | 5.20 |