Assay Detail
Functional
CHEMBL904908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of keratinization in vitamin A-deficient hamster trachea after 10 days by TOC assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetinae |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 10.20 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 11.00 |
| CHEMBL36878 | — | — | 1 | 10.10 |
| CHEMBL225795 | — | — | 1 | 9.49 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | — | 1 | - |
| CHEMBL25361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL36878 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL225795 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | - | — | - | |
| CHEMBL25361 | — | IC50 | = | 0.007 | nM | - |