Assay Detail
Functional
CHEMBL904909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of terminal differentiation in mouse F9 cells assessed by measuring secreted plasminogen activator activity after 3 days
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | F9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.26 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 10.00 |
| CHEMBL225795 | — | — | 1 | 9.52 |
| CHEMBL25361 | — | — | 1 | 9.00 |
| CHEMBL36878 | — | — | 1 | 8.52 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL225795 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL25361 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL36878 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | - | — | - |