Assay Detail
Functional
CHEMBL904920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of retinoid-resistant MDA-MB-231 cells after 72 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.84 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176252 | — | — | 1 | 5.75 |
| CHEMBL375062 | — | — | 1 | 5.20 |
| CHEMBL226068 | — | — | 1 | 4.85 |
| CHEMBL376571 | — | — | 1 | 4.75 |
| CHEMBL226021 | — | — | 1 | 4.72 |
| CHEMBL449401 | — | — | 1 | 4.68 |
| CHEMBL227623 | — | — | 1 | 4.62 |
| CHEMBL227622 | — | — | 1 | 4.15 |
| CHEMBL390158 | — | — | 1 | - |
| CHEMBL227678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176252 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL375062 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL226068 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL376571 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL226021 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL449401 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL227623 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL227622 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL390158 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL227678 | — | IC50 | > | 10000.0 | nM | - |