Assay Detail
Binding
CHEMBL904929
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Inhibition of CD45 PTP by fluorescence spectrometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Protein tyrosine phosphatase receptor type C-associated protein (CHEMBL4806) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.78 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227622 | — | — | 1 | 5.92 |
| CHEMBL376571 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227622 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL376571 | — | IC50 | = | 2300.0 | nM | 5.64 |