Assay Detail
Functional
CHEMBL904977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Apoptosis inducing activity in human H1299 cells by caspase activation assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 3. Structure-activity relationships of fused rings at the 7,8-positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 6.94 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229110 | — | — | 1 | 7.89 |
| CHEMBL228364 | — | — | 1 | 7.66 |
| CHEMBL375724 | — | — | 1 | 7.60 |
| CHEMBL228947 | — | — | 1 | 7.52 |
| CHEMBL373958 | — | — | 1 | 7.37 |
| CHEMBL228768 | — | — | 1 | 7.28 |
| CHEMBL439196 | — | — | 1 | 7.24 |
| CHEMBL228306 | — | — | 1 | 7.23 |
| CHEMBL265140 | — | — | 1 | 7.19 |
| CHEMBL388797 | — | — | 1 | 7.18 |
| CHEMBL228363 | — | — | 1 | 7.17 |
| CHEMBL375033 | — | — | 1 | 7.11 |
| CHEMBL388394 | — | — | 1 | 7.10 |
| CHEMBL439011 | — | — | 1 | 7.03 |
| CHEMBL228888 | — | — | 1 | 7.03 |
| CHEMBL388798 | — | — | 1 | 7.02 |
| CHEMBL228775 | — | — | 1 | 6.92 |
| CHEMBL388071 | — | — | 1 | 6.89 |
| CHEMBL389642 | — | — | 1 | 6.89 |
| CHEMBL229331 | — | — | 1 | 6.89 |
| CHEMBL228307 | — | — | 1 | 6.85 |
| CHEMBL373957 | — | — | 1 | 6.85 |
| CHEMBL389630 | — | — | 1 | 6.82 |
| CHEMBL228893 | — | — | 1 | 6.82 |
| CHEMBL228997 | — | — | 1 | 6.75 |
| CHEMBL228943 | — | — | 1 | 6.72 |
| CHEMBL229389 | — | — | 1 | 6.54 |
| CHEMBL228826 | — | — | 1 | 6.37 |
| CHEMBL229329 | — | — | 1 | 6.36 |
| CHEMBL229054 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229110 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL228364 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL375724 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL228947 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL373958 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL228768 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL439196 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL228306 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL265140 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL388797 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL228363 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL375033 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL388394 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL439011 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL228888 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL388798 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL228775 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL388071 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL389642 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL229331 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL228307 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL373957 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL389630 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL228893 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL228997 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL228943 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL229389 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL228826 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL229329 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL229054 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL390278 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL229109 | — | EC50 | = | 2720.0 | nM | 5.57 |